drying of APIs
AVA HVW-VT series drying mixers with their sophisticated vertical design offer top-of-the-line, highly reproducible product quality, maximum safety, and utmost ease of operation. The vertical drying mixers are equipped with a top-driven, rotating and self-centering helix with bearing and seal which are external to the product chamber. Contamination of high-quality APIs is thus reliably prevented. The large heating surface implemented as a heated double jacket, as well as the optionally heated shaft and helix, ensure optimal heat transfer, meaning the product is heated up quickly and uniformly. The vacuum lowers the boiling point and accelerates drying. The product is continuously homogenized in the vessel during the drying process, with no temperature or moisture gradient in the product at any point. After drying, the product is discharged into the cone outlet via a ball segment valve. To prevent issues such as cross-contamination, CIP cleaning nozzles ensure coverage of the entire interior and the filter housing when the machine is closed. With GMP designs and the use of FDA-compliant, pharmaceutical-compliant materials and seals, the highest production reliability is ensured. An interesting alternative is the horizontal AVA HTC-VT series drying mixers with one-sided shaft bearing and large inspection door. The mixer blades are welded to the shaft and span the entire interior of the double jacket-heated drying mixer with no cavity. The shaft is sealed with gas-cooled AVA lip seals. Because it is mounted on one side in a reinforced gear, the drive unit can be placed outside the clean room while the FDA-compliant active unit performs its mixing task inside the clean room. On the opposite side, there is a large inspection door. It is suspended sideways, heated separately, and provides optimal accessibility to the interior.
vertical mixers for small api throughputs
In addition to homogenizing, AVA vertical mixers are highly suited for use as bunker mixers between an inverting filter centrifuge mixer and a fluidized bed dryer. The centrifuge is specially designed for rapid filtration of small batches. A fluidized bed dryer typically requires larger batch volumes to operate efficiently. Therefore, the centrifuge first takes small amounts of the active ingredient, which has the consistency of a pasty mass, filters them, and empties them into the AVA vertical mixer. The AVA mixer moves the product slowly to avoid compactions. As soon as a sufficiently large batch volume is reached (detected by weighing cells), it is emptied into the fluidized bed dryer. The process thus takes place in semi-batch mode. In this process, the AVA vertical mixer forms the ideal bridge between the small centrifuge batches and the fluidized bed dryer, which requires larger volumes.